ParkinsonCanadaV1, Main, Exploration, bibRecord, 000714

Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

Identifieur interne : 000714 ( Main/Exploration ); précédent : 000713; suivant : 000715

Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

Auteurs : Ziv Gan-Or [Canada] ; Patrick A. Dion [Canada] ; Guy A. Rouleau [Canada]

Source :

Autophagy [ 1554-8627 ] ; 2015.

RBID : PMC:4590678

English descriptors

KwdEn :
- Animals, Autophagy (genetics), Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Lysosomal Storage Diseases (genetics), Lysosomes (genetics), Parkinson Disease (genetics).
MESH :
- genetics : Autophagy, Lysosomal Storage Diseases, Lysosomes, Parkinson Disease.
- Animals, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans.

Abstract

Parkinson disease (PD), once considered as a prototype of a sporadic disease, is now known to be considerably affected by various genetic factors, which interact with environmental factors and the normal process of aging, leading to PD. Large studies determined that the hereditary component of PD is at least 27%, and in some populations, single genetic factors are responsible for more than 33% of PD patients. Interestingly, many of these genetic factors, such as LRRK2, GBA, SMPD1, SNCA, PARK2, PINK1, PARK7, SCARB2, and others, are involved in the autophagy-lysosome pathway (ALP). Some of these genes encode lysosomal enzymes, whereas others correspond to proteins that are involved in transport to the lysosome, mitophagy, or other autophagic-related functions. Is it possible that all these factors converge into a single pathway that causes PD? In this review, we will discuss these genetic findings and the role of the ALP in the pathogenesis of PD and will try to answer this question. We will suggest a novel hypothesis for the pathogenic mechanism of PD that involves the lysosome and the different autophagy pathways.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590678

DOI: 10.1080/15548627.2015.1067364
PubMed: 26207393
PubMed Central: 4590678

Affiliations:

Canada

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<front><div type="abstract" xml:lang="en"><p>Parkinson disease (PD), once considered as a prototype of a sporadic disease, is now known to be considerably affected by various genetic factors, which interact with environmental factors and the normal process of aging, leading to PD. Large studies determined that the hereditary component of PD is at least 27%, and in some populations, single genetic factors are responsible for more than 33% of PD patients. Interestingly, many of these genetic factors, such as <italic>LRRK2</italic>
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La maladie de Parkinson au Canada (serveur d'exploration)

Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.